Research Articles
CRISPR vs. Base Editing: A Comprehensive Comparison of Precision, Safety, and Therapeutic Potential
This article provides a detailed technical comparison of CRISPR-Cas9 gene editing and base editing platforms for researchers and drug development professionals.
CRISPR Toxicity: Understanding Mechanisms and Strategies for Minimizing Off-Target Effects in Therapeutic Applications
This article provides a comprehensive, current overview of CRISPR-Cas system toxicity for researchers and drug development professionals.
SpCas9-HF1 and eSpCas9: High-Fidelity CRISPR-Cas9 Variants for Precision Genome Editing
This article provides a comprehensive analysis of two pioneering high-fidelity CRISPR-Cas9 variants: SpCas9-HF1 and eSpCas9.
CRISPR Spacer Acquisition: Mechanisms, Methods, and Therapeutic Applications in Viral DNA Capture
This comprehensive review examines the molecular mechanisms of CRISPR spacer acquisition from viral DNA, a foundational adaptive immunity process in prokaryotes.
CRISPR Screening: Unlocking Genetic Interactions & Dependencies for Target Discovery
This comprehensive guide explores CRISPR screening methodologies for identifying genetic interactions and dependencies, essential for modern drug discovery.
CRISPR Screening in Drug Discovery: Unlocking Novel Targets and Accelerating Therapeutic Development
This article provides a comprehensive guide to leveraging CRISPR screening for drug discovery and target identification.
CRISPR Screen Sequencing Depth: A Complete Guide for Researchers in 2024
This comprehensive guide explores the critical role of sequencing depth in CRISPR screen success, tailored for researchers, scientists, and drug development professionals.
Minimizing CRISPR Off-Target Effects: A 2024 Guide to Screening Strategies, Best Practices, and Clinical Relevance
This comprehensive guide details the critical strategies for identifying and reducing CRISPR-Cas off-target effects, a primary safety concern for research and therapeutic applications.
Beyond the Screen: A Comprehensive Workflow Guide for Confirming CRISPR Screen Hits
This article provides researchers, scientists, and drug development professionals with a complete, modern framework for validating hits from CRISPR knockout, activation, and inhibition screens.
Unlocking Cancer's Secrets: How CRISPR Screens Are Revolutionizing Immunotherapy Target Discovery
This article provides a comprehensive guide to using CRISPR screening for identifying novel immunotherapy targets.